I don't see why you'd avoid them. Supersets are one of the best intensity techniques out there. Many people only train in supersets and get great results. You can do a lot of different things with these. One way is to use antagonist muscles to really work and pump a specific area of your body. An example would be to do bench presses, then chins, then something like pullovers. This will basically pump your entire upper body. You can also use them to really fatigue one specific area of your body. If you were doing shoulders you could do an exercise for each head of the deltoid all in sequence. Like military press into side laterals into bent over laterals. It's very demanding but enables you do really work the muscle to its foundation. I like to do arm supersets because I really don't enjoy working arms, and like to make the workout short and very effective. I'll typically do something like barbell curls into skull-crushers into wrist curls. This will make your entire arm pumped and you'll know you worked out.
Milos Sarcev is a huge proponent of giant set training, which is superset training taken to its limits. Obviously Milos is enhanced so you don't want to follow everything exactly, but he will do twelve exercises in a row for one body part without stopping. Four rotations of that and you will be guaranteed to work every fiber and cell in your muscles. Dave Draper is also huge into more moderate supersets and has a lot of info on his site. He's been doing them since the 60s so it's a proven method.
It's mainly a way of adding extra stress to your muscles to achieve maximum results. Drops sets, rest/pause, negatives, forced reps, 21s, etc all have their uses.